Article
ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae.
Canadian journal of microbiology - 1 Apr 2009
García-Campusano Florencia, Anaya Víctor-Hugo, Robledo-Arratia Luis, Quezada Héctor, Hernández Hugo, Riego Lina, González Alicia
Abstract excerpt
In the yeast Saccharomyces cerevisiae, the paralogous genes ALT1 and ALT2 have been proposed to encode alanine aminotransferase isozymes. Although in other microorganisms this enzyme constitutes the main pathway for alanine biosynthesis, its role in S. cerevisiae had remained unclear. Results presented in this paper show that under respiratory conditions, Alt1p constitutes the sole pathway for alanine...
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