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Article

Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms.

Journal of the American Heart Association - 18 Jan 2013

Kakinuma Yoshihiko, Tsuda Masayuki, Okazaki Kayo, Akiyama Tsuyoshi, Arikawa Mikihiko, Noguchi Tatsuya, Sato Takayuki

Abstract excerpt

BACKGROUND: Murine and human ventricular cardiomyocytes rich in acetylcholine (Ach) receptors are poorly innervated by the vagus, compared with whole ventricular innervation by the adrenergic nerve. However, vagal nerve stimulation produces a favorable outcome even in the murine heart, despite relatively low ventricular cholinergic nerve density. Such a mismatch and missing link suggest the existence of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mitochondria, Heart

Share to Myocardial Reperfusion Injury

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Source

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Identifiers

PMID: 23525439
DOI: 10.1161/JAHA.112.004887
PMCID: PMC3603257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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