Article
Different profiles of IL-10+IFN-gamma-IL-4-CD4+ T cells in the peripheral blood in atopic and non-atopic asthmatics.
Respiration; international review of thoracic diseases - 1 Jan 2008
Matsumoto K, Inoue H, Tsuda M, Nakano T, Komori M, Fukuyama S, Nakanishi Y
Abstract excerpt
BACKGROUND: The impaired production of interleukin (IL) 10 from regulatory T cells has been proposed as a causal mechanism of asthma. Although IL-10-producing (IL-10+) T cells are detectable in the peripheral blood, their significance in the pathophysiology of asthma remains uncertain. OBJECTIVES: This study aimed to investigate the profile of circulating IL-10+CD4+ T cells in atopic and non-atopic asthma....
Topics
- Adult
- Asthma
- Female
- Humans
- Interferon-gamma
- Interleukin-10
- Interleukin-4
- Male
- Phenotype
- T-Lymphocytes, Regulatory