Article
Phenotypic screening with oleaginous microalgae reveals modulators of lipid productivity.
ACS chemical biology - 17 May 2013
Franz Annaliese K, Danielewicz Megan A, Wong Diana M, Anderson Lisa A, Boothe Jordan R
Abstract excerpt
Here we describe the first phenotypic screening with microalgae to study lipid metabolism and to discover organic small molecules as chemical triggers that increase growth and lipid production. A microplate assay has been developed for analysis of intracellular lipids using Nile Red fluorescence in order to screen a collection of diverse bioactive organic molecules (e.g., kinase inhibitors) with four strains of...
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