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Article

Plasminogen activator inhibitor 1 4G/5G and -844G/A variants in idiopathic recurrent pregnancy loss.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Sept 2013

Magdoud Kalthoum, Herbepin Viviana G, Touraine Renaud, Almawi Wassim Y, Mahjoub Touhami

Abstract excerpt

PROBLEM: Plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis, and the common promoter region variants -675G/A (4G/5G) and -844G/A are associated with increased thrombotic risk. Despite evidence linking altered fibrinolysis with adverse pregnancy events, including idiopathic recurrent pregnancy loss (RPL), the contribution of PAI-1 variants to RPL risk remains controversial. We investigated the...

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PMID: 23521508
DOI: 10.1111/aji.12116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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