Maternal Thrombophilic and Hypofibrinolytic Genetic Variants in Idiopathic Recurrent Pregnancy Loss: a Continuing Mystery.

doi:10.1007/s43032-022-01063-1

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Article

Maternal Thrombophilic and Hypofibrinolytic Genetic Variants in Idiopathic Recurrent Pregnancy Loss: a Continuing Mystery.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2023

Younis Mahmoud, Ali Mohamed A M, Ghareeb Doaa A, Youssef Rehab, Fathy Shadia A

Abstract excerpt

Despite the fact that multiple recurrent pregnancy loss (RPL) etiologies have been identified, 50-70% of RPL cases remain enigmatic, and idiopathic RPL is still a serious medical challenge. A plethora of studies have investigated the correlation of RPL with variations in coagulation and/or fibrinolytic factors-encoding genes. Notwithstanding, evidence for a link between these variations and RPL remains...

Topics

Pregnancy
Humans
Female
Genotype
Plasminogen Activator Inhibitor 1
Alleles
Abortion, Habitual
Methylenetetrahydrofolate Reductase (NADPH2)
Thrombophilia
Apolipoproteins E

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PMID: 35969362
DOI: 10.1007/s43032-022-01063-1

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