Article
Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin.
Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013
Ubelmann Florent, Chamaillard Mathias, El-Marjou Fatima, Simon Anthony, Netter Jeanne, Vignjevic Danijela, Nichols Buford L, Quezada-Calvillo Roberto, Grandjean Teddy, Louvard Daniel, Revenu Céline, Robine Sylvie
Abstract excerpt
Efficient wound healing is required to maintain the integrity of the intestinal epithelial barrier because of its constant exposure to a large variety of environmental stresses. This process implies a partial cell depolarization and the acquisition of a motile phenotype that involves rearrangements of the actin cytoskeleton. Here we address how polarized enterocytes harboring actin-rich apical microvilli undergo...
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