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Article

Gadd45g is essential for primary sex determination, male fertility and testis development.

PloS one - 1 Jan 2013

Johnen Heiko, González-Silva Laura, Carramolino Laura, Flores Juana Maria, Torres Miguel, Salvador Jesús M

Abstract excerpt

In humans and most mammals, differentiation of the embryonic gonad into ovaries or testes is controlled by the Y-linked gene SRY. Here we show a role for the Gadd45g protein in this primary sex differentiation. We characterized mice deficient in Gadd45a, Gadd45b and Gadd45g, as well as double-knockout mice for Gadd45ab, Gadd45ag and Gadd45bg, and found a specific role for Gadd45g in male fertility and testis...

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Share to Fertility
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gonadal Dysgenesis, 46,XY

Share to Intracellular Signaling Peptides and Proteins

Share to Sertoli Cells

Share to Sex Determination Processes

Share to Sex-Determining Region Y Protein

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 23516551
DOI: 10.1371/journal.pone.0058751
PMCID: PMC3596291

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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