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Article

Association between<i>TCF7L2</i>Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide

1 Jan 2013

Abstract excerpt

Previous studies showed associations between variants in TCF7L2 gene and the therapeutic response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of ATP-sensitive potassium (KATP) channel. The aim of the present study was to compare TCF7L2 genotype specific effect of gliclazide binding to KATP channel A-site (Group 1) with sulfonylureas binding to AB-site (Group 2). A total of 101...

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Identifiers

PMID: 23509454
DOI: 10.1155/2013/374858

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