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Article

The Effect of Aflatoxin B1 on Tumor-Related Genes and Phenotypic Characters of MCF7 and MCF10A Cells.

International journal of molecular sciences - 6 Oct 2022

Adam Mowaffaq Adam Ahmed, Kamal Laina Zarisa Muhd, Kanakal Mahibub, Babu Dinesh, Dahham Saad Sabbar, Tabana Yasser, Lok Bronwyn, Bermoy Brittany M, Yunus Muhammad Amir, Than Leslie Thian Lung, Barakat Khaled, Sandai Doblin

Abstract excerpt

The fungal toxin aflatoxin B1 (AB1) and its reactive intermediate, aflatoxin B1-8, 9 epoxide, could cause liver cancer by inducing DNA adducts. AB1 exposure can induce changes in the expression of several cancer-related genes. In this study, the effect of AB1 exposure on breast cancer MCF7 and normal breast MCF10A cell lines at the phenotypic and epigenetic levels was investigated to evaluate its potential in...

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Identifiers

PMID: 36233156
DOI: 10.3390/ijms231911856
PMCID: PMC9570345

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