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Article

Perfluorooctanoic acid alters T lymphocyte phenotypes and cytokine expression in mice.

Environmental toxicology - 1 Dec 2009

Son Hee-Young, Lee Soyoung, Tak Eun-Nam, Cho Hae-Sung, Shin Hong-In, Kim Sang-Hyun, Yang Jae-Ho

Abstract excerpt

Perfluorooctanoic acid (PFOA) has been used in commercial applications and detected in environmental matrices. This study focuses on whether PFOA affects the function of immune organs (spleen and thymus). Male ICR mice were exposed to 0, 2, 10, 50, and 250 ppm of PFOA in drinking water for 21 days. PFOA differently altered T lymphocyte populations. In the spleen, all doses of PFOA decreased CD8(+) lymphocytes;...

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Identifiers

PMID: 19051282
DOI: 10.1002/tox.20459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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