The HLA-G 14-bp insertion/deletion polymorphism is associated with chronic hepatitis B in Southern Brazil: A case-control study.

doi:10.1016/j.humimm.2020.01.003

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Article

The HLA-G 14-bp insertion/deletion polymorphism is associated with chronic hepatitis B in Southern Brazil: A case-control study.

Human immunology - 1 Jan 2000

Michel Wolf Jonas, Zingalli Bueno Pereira Vagner Reinaldo, Zanetti Ballardin Roncato Patrícia Andréia, Castagna Wortmann André, Stumm Glaucia Zuleide, Oliveira da Silva Fernando, Lunge Vagner Ricardo, Simon Daniel

Abstract excerpt

There is growing evidence that the non-classical HLA-G has a role in the process of the immune response against pathogens, including HBV and HIV. Previous studies demonstrated that a 14-bp insertion/deletion (indel) polymorphism at 3'-untranslated region of HLA-G gene interferes in the mRNA stability and expression. The present study aimed to evaluate the association of the 14-bp indel polymorphism (rs371194629)...

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PMID: 31955869
DOI: 10.1016/j.humimm.2020.01.003

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