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Article

Clinical and biologic implications of recurrent genomic aberrations in myeloma

19 May 2003

Abstract excerpt

Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple myeloma (MM) and include, among others, translocations of the immunoglobulin heavy chain locus (IgH). IgH translocations in MM result in the up-regulation of oncogenes, and include more commonly t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23). Based on the recurrent nature of these translocations and their finding since the early...

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Identifiers

PMID: 12576322
DOI: 10.1182/blood-2002-10-3017

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