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Article

A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss.

Mechanisms of ageing and development - 1 Jan 2000

Nolan Lisa S, Cadge Barbara A, Gomez-Dorado Miriam, Dawson Sally J

Abstract excerpt

UNLABELLED: Genetic variation in superoxide dismutase 2 (SOD2) is implicated in several ageing pathologies and with noise-induced hearing loss. Here, we have investigated the role of SOD2 promoter variants in age related hearing loss (ARHL). METHODS: Putative regulatory variants identified in the SOD2 promoter using bioinformatics were functionally evaluated in an inner-ear-derived cell line (OC-2). Variants with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23500038
DOI: 10.1016/j.mad.2013.02.009

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SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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