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Exome sequencing identifies a new candidate mutation for susceptibility to diabetes in a family with highly aggregated type 2 diabetes.

Molecular genetics and metabolism - 1 May 2013

Tanaka Daisuke, Nagashima Kazuaki, Sasaki Mayumi, Funakoshi Shogo, Kondo Yasushi, Yasuda Koichiro, Koizumi Akio, Inagaki Nobuya

Abstract excerpt

The aim of this study was to investigate the genetic background of familial clustering of diabetes using genome-wide linkage analysis combined with exome sequencing. We recruited a Japanese family with a 3-generation history of diabetes. The family comprised 16 members, 13 having been diagnosed with diabetes. Nine members had been diagnosed before the age of 40. Linkage analysis was performed assuming an...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Identifiers

PMID: 23499280
DOI: 10.1016/j.ymgme.2013.02.010

Genes

EEA1

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