Article
Frequent loss of genome gap region in 4p16.3 subtelomere in early-onset type 2 diabetes mellitus.
Experimental diabetes research - 1 Jan 2011
Kudo Hirohito, Emi Mitsuru, Ishigaki Yasushi, Tsunoda Uiko, Hinokio Yoshinori, Ishii Miho, Sato Hidenori, Yamada Tetsuya, Katagiri Hideki, Oka Yoshitomo
Abstract excerpt
A small portion of Type 2 diabetes mellitus (T2DM) is familial, but the majority occurs as sporadic disease. Although causative genes are found in some rare forms, the genetic basis for sporadic T2DM is largely unknown. We searched for a copy number abnormality in 100 early-onset Japanese T2DM patients (onset age <35 years) by whole-genome screening with a copy number variation BeadChip. Within the 1.3-Mb...
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