Article
Gender-dependent histone deacetylases injury may contribute to differences in liver recovery rates of male and female mice.
Transplantation proceedings - 1 Mar 2013
Wang Y, Ye F, Ke Q, Wu Q, Yang R, Bu H
Abstract excerpt
BACKGROUND: Hepatocytes undergo DNA synthesis shortly after liver damage triggered by partial hepatectomy (PH). This study revealed that the rate of liver damage recovery is gender-dependent. Furthermore, histone deacetylase (HDAC) epigenetic factors were discovered, at least in part, to govern the different liver recovery rates that were observed for male and female mice. MATERIALS AND METHODS: Experimental mice...
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