Article
Association of estrogen receptor alpha polymorphisms with symptoms of autism among Chinese Han children.
Neuro endocrinology letters - 1 Nov 2016
Wang Xuelai, Liang Shuang, Fujisawa Takashi X, Nishitani Shota, Tomoda Akemi, Zou Mingyang, Li Yang, Wu Lijie, Shinohara Kazuyuki
Abstract excerpt
OBJECTIVES: Autism has a significant sex difference. This implies that the sex hormones might have effect on autism. Estrogens play an important role in early nervous system development and sex differentiation through estrogen receptors in brain. Thus, we tested the hypothesis that estrogen receptor alpha (ESR1) gene affects the pathogenesis of autism and related symptoms. METHODS: Genotypes of rs11155819 and...
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