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Article

CHD6 promotes broad nucleosome eviction for transcriptional activation in prostate cancer cells

21 Nov 2022

Abstract excerpt

Despite being a member of the chromodomain helicase DNA-binding protein family, little is known about the exact role of CHD6 in chromatin remodeling or cancer disease. Here we show that CHD6 binds to chromatin to promote broad nucleosome eviction for transcriptional activation of many cancer pathways. By integrating multiple patient cohorts for bioinformatics analysis of over a thousand prostate cancer datasets,...

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PMID: 36408932
DOI: 10.1093/nar/gkac1090

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