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Article

C677T polymorphism of methylenetetrahydrofolate reductase may contribute to cervical cancer risk in complete over-dominant model.

Medical hypotheses - 1 May 2013

Chen Hongmei, Zhu Jin

Abstract excerpt

PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate. The single nucleotide polymorphism (SNP), C677T (Ala>Val, rs1801133), has been confirmed to decrease the enzyme activity. The association between C677T and cervical cancer susceptibility has been widely studied. However, the results were inconsistent. In order to elucidate the role of this SNP in cervical cancer, a...

Topics

Female
Genes, Dominant
Genetic Predisposition to Disease
Humans
Methylenetetrahydrofolate Dehydrogenase (NADP)
Polymorphism, Single Nucleotide
Prevalence
Risk Assessment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Uterine Cervical Neoplasms

Source

Identifiers

PMID: 23490201
DOI: 10.1016/j.mehy.2013.01.025

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23490201-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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