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Article

Mutational analysis of the internal membrane proximal domain of the HIV glycoprotein C-terminus.

Virology - 25 May 2013

Pfeiffer Tanya, Erkelenz Steffen, Widera Marek, Schaal Heiner, Bosch Valerie

Abstract excerpt

This study focuses on the long stretch of highly conserved amino acids in the membrane proximal part of the HIV-1 cytoplasmic tail (Env amino acids (aa) 706-718) upstream of the overlap with the tat and rev second coding exons. Changes in Env aa 713 and 715, although they did not affect Env function, abrogated replicative spread. Other amino acid substitutions, i.e., 706-712, 714 and 716, despite their...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23481247
DOI: 10.1016/j.virol.2013.01.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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