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Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine.

mBio - 31 Aug 2021

Dos Reis Thaila Fernanda, Horta Maria Augusta Crivelente, Colabardini Ana Cristina, Fernandes Caroline Mota, Silva Lilian Pereira, Bastos Rafael Wesley, Fonseca Maria Vitória de Lazari, Wang Fang, Martins Celso, Rodrigues Márcio L, Silva Pereira Cristina, Del Poeta Maurizio, Wong Koon Ho, Goldman Gustavo H

Abstract excerpt

Aspergillus fumigatus is an important fungal pathogen and the main etiological agent of aspergillosis, a disease characterized by a noninvasive process that can evolve to a more severe clinical manifestation, called invasive pulmonary aspergillosis (IPA), in immunocompromised patients. The antifungal arsenal to threat aspergillosis is very restricted. Azoles are the main therapeutic approach to control IPA, but...

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PMID: 34372704
DOI: 10.1128/mBio.01458-21
PMCID: PMC8406317

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