Article
Oligosaccharide Y specific monoclonal antibody and its isotype switch variants.
Hybridoma - 1 Apr 1990
Steplewski Z, Blaszczyk-Thurin M, Lubeck M, Loibner H, Scholz D, Koprowski H
Abstract excerpt
Isotype switch variants of the IgG3 secreting hybridoma BR55-2 were developed with gamma 1, gamma 2b and gamma 2a heavy chains. The variants have the same affinity for antigen and expected affinities for the Fc receptor. The Y antigen defined by MAb BR55-2 has a restricted distribution to breast,...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Affinity
- Antibody Specificity
- Antigens
- Breast Neoplasms
- Carbohydrate Sequence
- Cell Line
- Cells, Cultured
- Genetic Variation
- Glycolipids
- Glycoproteins
- Glycosphingolipids
- Humans
- Immunoglobulin G
- Immunoglobulin Isotypes
- Mice
- Mice, Inbred BALB C
