Article
Detection of Lewis(a) antigen in sera of ovarian carcinoma patients by MOv2-MOv8 double-determinant radioimmunoassay.
The International journal of biological markers - 1 Jan 2000
Mantovani L, Azzini V, Canevari S, Danzi R, Fontanelli R, Leoni F, Ménard S, Miotti S, Pasquali M, Zambetti M
Abstract excerpt
The monoclonal antibodies MOv2 and MOv8, raised against ovarian carcinoma, were found to be directed against two non-crossreacting epitopes expressed on the same molecule. Immunochemical analysis of the MOv8 recognized epitope showed that the Le(a) oligosaccharide, or commercial anti-Le(a) MAb, but not the anti-Le(b) MAb, prevented Ov8 binding to the reference target cell line (SW626), indicating that it is...
Topics
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Epitopes
- Female
- Humans
- Immunoradiometric Assay
- Lewis Blood Group Antigens
- Ovarian Neoplasms
- Phenotype