Article
[Personal genomics for Alzheimer's disease].
Brain and nerve = Shinkei kenkyu no shinpo - 1 Mar 2013
Kuwano Ryozo, Hara Norikazu
Abstract excerpt
Alzheimer's disease (AD) is the most common type of dementia in the elderly and has multiple causes. The amyloid precursor protein (APP), presenilin1 (PSEN1), and presenilin2 (PSEN2) genes were identified as causative genes in a small number of families with autosomal dominant early-onset forms of AD (ADEOAD). However, many AD cases are sporadic and the late-onset type, which develops after 65 years of age. The...
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