Article
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
Human molecular genetics - 1 Jul 2013
Stambolian Dwight, Wojciechowski Robert, Oexle Konrad, Pirastu Mario, Li Xiaohui, Raffel Leslie J, Cotch Mary Frances, Chew Emily Y, Klein Barbara, Klein Ronald, Wong Tien Y, Simpson Claire L, Klaver Caroline C W, van Duijn Cornelia M, Verhoeven Virginie J M, Baird Paul N, Vitart Veronique, Paterson Andrew D, Mitchell Paul, Saw Seang Mei, Fossarello Maurizio, Kazmierkiewicz Krista, Murgia Federico, Portas Laura, Schache Maria, Richardson Andrea, Xie Jing, Wang Jie Jin, Rochtchina Elena, Viswanathan Ananth C, Hayward Caroline, Wright Alan F, Polasek Ozren, Campbell Harry, Rudan Igor, Oostra Ben A, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Amin Najaf, Karssen Lennart C, Vingerling Johannes R, Hosseini S M, Döring Angela, Bettecken Thomas, Vatavuk Zoran, Gieger Christian, Wichmann H-Erich, Wilson James F, Fleck Brian, Foster Paul J, Topouzis Fotis, McGuffin Peter, Sim Xueling, Inouye Michael, Holliday Elizabeth G, Attia John, Scott Rodney J, Rotter Jerome I, Meitinger Thomas, Bailey-Wilson Joan E
Abstract excerpt
Visual refractive errors (REs) are complex genetic traits with a largely unknown etiology. To date, genome-wide association studies (GWASs) of moderate size have identified several novel risk markers for RE, measured here as mean spherical equivalent (MSE). We performed a GWAS using a total of 7280 samples from five cohorts: the Age-Related Eye Disease Study (AREDS); the KORA study ('Cooperative Health Research...
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