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Article

Identification of novel loci influencing refractive error in East Asian populations using an extreme phenotype design.

Journal of genetics and genomics = Yi chuan xue bao - 1 Jan 2022

Han Xiaotong, Liu Tianzi, Ding Xiaohu, Liu Jialin, Lin Xingyan, Wang Decai, Riaz Moeen, Baird Paul N, Xie Zhi, Cheng Yuan, Li Yi, Mori Yuki, Miyake Masahiro, Li Hengtong, Cheng Ching-Yu, Zeng Changqing, Ohno-Matsui Kyoko, Zhou Xiangtian, Liu Fan, He Mingguang

Abstract excerpt

The global "myopia boom" has raised significant international concerns. Despite a higher myopia prevalence in Asia, previous large-scale genome-wide association studies (GWASs) were mostly based on European descendants. Here, we report a GWAS of spherical equivalent (SE) in 1852 Chinese Han individuals with extreme SE from Guangzhou (631 < -6.00D and 574 > 0.00D) and Wenzhou (593 < -6.00D and 54 > -1.75D),...

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Identifiers

PMID: 34520856
DOI: 10.1016/j.jgg.2021.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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