Article
Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.
PloS one - 1 Jan 2014
Simpson Claire L, Wojciechowski Robert, Oexle Konrad, Murgia Federico, Portas Laura, Li Xiaohui, Verhoeven Virginie J M, Vitart Veronique, Schache Maria, Hosseini S Mohsen, Hysi Pirro G, Raffel Leslie J, Cotch Mary Frances, Chew Emily, Klein Barbara E K, Klein Ronald, Wong Tien Yin, van Duijn Cornelia M, Mitchell Paul, Saw Seang Mei, Fossarello Maurizio, Wang Jie Jin, Polašek Ozren, Campbell Harry, Rudan Igor, Oostra Ben A, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Amin Najaf, Karssen Lennart C, Vingerling Johannes R, Döring Angela, Bettecken Thomas, Bencic Goran, Gieger Christian, Wichmann H-Erich, Wilson James F, Venturini Cristina, Fleck Brian, Cumberland Phillippa M, Rahi Jugnoo S, Hammond Chris J, Hayward Caroline, Wright Alan F, Paterson Andrew D, Baird Paul N, Klaver Caroline C W, Rotter Jerome I, Pirastu Mario, Meitinger Thomas, Bailey-Wilson Joan E, Stambolian Dwight
Abstract excerpt
Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the optical power of the eye and its axial length that causes object images to be focused off the retina. The two major subtypes of RE are myopia (nearsightedness) and hyperopia (farsightedness), which represent opposite ends of the distribution of the quantitative measure of spherical refraction. We performed a fixed...
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