A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.

doi:10.1038/ng.663

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Article

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.

Nature genetics - 1 Oct 2010

Solouki Abbas M, Verhoeven Virginie J M, van Duijn Cornelia M, Verkerk Annemieke J M H, Ikram M Kamran, Hysi Pirro G, Despriet Dominiek D G, van Koolwijk Leonieke M, Ho Lintje, Ramdas Wishal D, Czudowska Monika, Kuijpers Robert W A M, Amin Najaf, Struchalin Maksim, Aulchenko Yurii S, van Rij Gabriel, Riemslag Frans C C, Young Terri L, Mackey David A, Spector Timothy D, Gorgels Theo G M F, Willemse-Assink Jacqueline J M, Isaacs Aaron, Kramer Rogier, Swagemakers Sigrid M A, Bergen Arthur A B, van Oosterhout Andy A L J, Oostra Ben A, Rivadeneira Fernando, Uitterlinden André G, Hofman Albert, de Jong Paulus T V M, Hammond Christopher J, Vingerling Johannes R, Klaver Caroline C W

Abstract excerpt

Refractive errors are the most common ocular disorders worldwide and may lead to blindness. Although this trait is highly heritable, identification of susceptibility genes has been challenging. We conducted a genome-wide association study for refractive error in 5,328 individuals from a Dutch pop...

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PMID: 20835239
DOI: 10.1038/ng.663
PMCID: PMC4115149

Genes

ACTC1
GJD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20835239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.PMID 20835239Read ↗

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.Semantic proximity Read ↗

A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.Semantic proximity Read ↗

Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study cohort.Semantic proximity Read ↗

Association of 15q14 and 15q25 with high myopia in Japanese.Semantic proximity Read ↗

Regional replication of association with refractive error on 15q14 and 15q25 in the Age-Related Eye Disease Study cohort.Semantic proximity Read ↗

Association study of 15q14 and 15q25 with high myopia in the Han Chinese population.Semantic proximity Read ↗

Association of markers at chromosome 15q14 in Chinese patients with moderate to high myopia.Semantic proximity Read ↗

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.Semantic proximity Read ↗

A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.Semantic proximity Read ↗

Evaluating the association between pathological myopia and SNPs in RASGRF1. ACTC1 and GJD2 genes at chromosome 15q14 and 15q25 in a Chinese population.Semantic proximity Read ↗

Association of 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations.Semantic proximity Read ↗

Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future.Semantic proximity Read ↗

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