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Article

Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cells

6 Mar 2013

Abstract excerpt

Multiple myeloma (MM) is an incurable hematological malignancy that causes most patients to eventually relapse and die from their disease. The 20S proteasome inhibitor bortezomib has emerged as an effective drug for MM treatment; however, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. We evaluated the involvement of mitochondria in resistance to bortezomib-induced cell...

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PMID: 23463417
DOI: 10.1002/ijc.28149

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