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Article

Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes.

PloS one - 1 Jan 2013

Hadad Ielham, Veithen Alex, Springael Jean-Yves, Sotiropoulou Panagiota A, Mendes Da Costa Agnès, Miot Françoise, Naeije Robert, De Deken Xavier, Entee Kathleen Mc

Abstract excerpt

Stroma cell-derived factor-1α (SDF-1α) is a cardioprotective chemokine, acting through its G-protein coupled receptor CXCR4. In experimental acute myocardial infarction, administration of SDF-1α induces an early improvement of systolic function which is difficult to explain solely by an anti-apoptotic and angiogenic effect. We wondered whether SDF-1α signaling might have direct effects on calcium transients and...

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Identifiers

PMID: 23460790
DOI: 10.1371/journal.pone.0056007
PMCID: PMC3584107

Genes

CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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