Article

Increased spontaneous Ca <sup>2+</sup> activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?

2023-10-26

Abstract excerpt

<h4>Background</h4> Studies of Purkinje cells (Pcells) from canine hearts have suggested an increase of Ca 2+ -release by the sarcoplasmic reticulum (SR) but also reported a potential augmentation of SR-Ca 2+ -uptake after MI. Abnormal increase of SR-Ca 2+ -uptake in heart cells is novel and contrasts with the reduction of this function in cells of failing heart. Our study examined the origin of this increased...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8aab4c5-caf1-5d79-8976-c20d406f0385
DOI: 10.1101/2023.10.23.563678

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased spontaneous Ca <sup>2+</sup> activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?DOI 10.1101/2023.10.23.563678Read

Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion InjurySemantic proximity Read

[Myocardial hypertrophy after myocardial infarct: what is the significance of phenotype changes in cardiocytes?].Semantic proximity Read

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalitiesSemantic proximity Read

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulationsSemantic proximity Read

<i>In Silico</i> Optimisation of Regenerative Cell Therapy in the Infarcted Human Ventricles to Mitigate Arrhythmic BurdenSemantic proximity Read

LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction.Semantic proximity Read

Remodelling Ca2+ signalling systems and cardiac hypertrophySemantic proximity Read

Mechanisms of ventricular arrhythmias elicited by coexistence of multiple electrophysiological remodeling in ischemia: a simulation studySemantic proximity Read

Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell GrowthSemantic proximity Read

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesSemantic proximity Read

Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only.Semantic proximity Read