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Article

Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis.

DNA repair - 4 Jun 2010

D'Agostino Vito G, Minoprio Anna, Torreri Paola, Marinoni Ilaria, Bossa Cecilia, Petrucci Tamara C, Albertini Alessandra M, Ranzani Guglielmina N, Bignami Margherita, Mazzei Filomena

Abstract excerpt

The MUTYH DNA glycosylase specifically removes adenine misincorporated by replicative polymerases opposite the oxidized purine 8-oxo-7,8-dihydroguanine (8-oxoG). A defective protein activity results in the accumulation of G>T transversions because of unrepaired 8-oxoG:A mismatches. In humans, MUTYH germline mutations are associated with a recessive form of familial adenomatous polyposis and colorectal cancer...

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Source

Identifiers

PMID: 20418187
DOI: 10.1016/j.dnarep.2010.03.008

Genes

MUTYH
SPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis.PMID 20418187Read ↗

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