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Article

Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene.

Blood - 25 Apr 2013

Saarinen Silva, Kaasinen Eevi, Karjalainen-Lindsberg Marja-Liisa, Vesanen Kari, Aavikko Mervi, Katainen Riku, Taskinen Minna, Kytölä Soili, Leppä Sirpa, Hietala Marja, Vahteristo Pia, Aaltonen Lauri A

Abstract excerpt

Primary mediastinal large B-cell lymphoma (PMBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) accounting for 2% to 4% of all non-Hodgkin lymphomas. We report a family of 3 siblings with PMBCL and their cousin with extranodal DLBCL. The histopathological characteristics of lymphomas of all 4 patients are similar, implying post-germinal center differentiation and growth deregulation by other mechanisms...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Histone-Lysine N-Methyltransferase

Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 23457195
DOI: 10.1182/blood-2012-06-437210

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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