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Article

Role of chitosan co-formulation in enhancing interleukin-12 delivery and antitumor activity.

Biomaterials - 1 May 2013

Yang Lirong, Zaharoff David A

Abstract excerpt

Local delivery systems that provide sustained, high concentrations of antitumor cytokines in the tumor microenvironment while minimizing systemic dissemination are needed to realize the potential of cytokine-based immunotherapies. Recently, co-formulations of cytokines with chitosan solutions have been shown to increase local cytokine retention and bioactivity. In particular, intratumoral (i.t.) injections of...

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Identifiers

PMID: 23453060
DOI: 10.1016/j.biomaterials.2013.02.031
PMCID: PMC3613143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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