Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius.

doi:10.1128/jb.172.6.3427-3434.1990

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Article

Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius.

Journal of bacteriology - 1 Jun 1990

Otten S L, Stutzman-Engwall K J, Hutchinson C R

Abstract excerpt

Genes for the biosynthesis of daunorubicin (daunomycin) and doxorubicin (adriamycin), important antitumor drugs, were cloned from Streptomyces peucetius (the daunorubicin producer) and S. peucetius subsp. caesius (the doxorubicin producer) by use of the actI/tcmIa and actIII polyketide synthase g...

Topics

Anthracyclines
Antibiotics, Antineoplastic
Cloning, Molecular
Daunorubicin
Gene Expression
Genes, Bacterial
Genetic Complementation Test
Mutation
Streptomyces

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