Article
Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius.
Journal of bacteriology - 1 Mar 1992
Colombo A L, Solinas M M, Perini G, Biamonti G, Zanella G, Caruso M, Torti F, Filippini S, Inventi-Solari A, Garofano L
Abstract excerpt
Two DNA fragments, ric1 and ric2, were isolated from the Streptomyces peucetius 7600 mutant, which produces daunorubicin and doxorubicin, on the basis of their abilities to confer doxorubicin and daunorubicin resistance to Streptomyces lividans. These two fragments are unrelated by restriction mapping and do not show any homology by Southern analysis, yet both of them increase the level of resistance 10-fold in...
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