Article
Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius.
Journal of bacteriology - 1 Mar 1992
Colombo A L, Solinas M M, Perini G, Biamonti G, Zanella G, Caruso M, Torti F, Filippini S, Inventi-Solari A, Garofano L
Abstract excerpt
Two DNA fragments, ric1 and ric2, were isolated from the Streptomyces peucetius 7600 mutant, which produces daunorubicin and doxorubicin, on the basis of their abilities to confer doxorubicin and daunorubicin resistance to Streptomyces lividans. These two fragments are unrelated by restriction ma...
Topics
- Cloning, Molecular
- Daunorubicin
- Doxorubicin
- Drug Resistance, Microbial
- Gene Expression Regulation, Bacterial
- Genes, Regulator
- Models, Biological
- Mutation
- Naphthacenes
- Nucleic Acid Hybridization
- RNA Precursors
- Restriction Mapping
- Streptomyces
- Transcription, Genetic