Article
Animal models of gene-environment interactions in schizophrenia.
Behavioural brain research - 7 Dec 2009
Ayhan Yavuz, Sawa Akira, Ross Christopher A, Pletnikov Mikhail V
Abstract excerpt
The pathogenesis of schizophrenia and related mental illnesses likely involves multiple interactions between susceptibility genes of small effects and environmental factors. Gene-environment interactions occur across different stages of neurodevelopment to produce heterogeneous clinical and pathological manifestations of the disease. The main obstacle for mechanistic studies of gene-environment interplay has been...
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