Animal models for schizophrenia via in utero gene transfer: understanding roles for genetic susceptibility factors in brain development.

Abstract excerpt

Genetic disturbances of brain development may underlie the pathophysiology of schizophrenia. Recent advances in molecular neurobiology suggest that some genetic risk factors for schizophrenia have multiple roles in various brain regions depending on the developmental stage. Furthermore, these factors are likely to act synergistically or epistatically in common molecular pathways, possibly contributing to disease...

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