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Article

Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.

The Biochemical journal - 15 Mar 2006

Song Bao-Liang, Wang Can-Hua, Yao Xiao-Min, Yang Li, Zhang Wen-Jing, Wang Zhen-Zhen, Zhao Xiao-Nan, Yang Jin-Bo, Qi Wei, Yang Xin-Ying, Inoue Kenji, Lin Zhi-Xin, Zhang Hui-Zhan, Kodama Tatsuhiko, Chang Catherine C Y, Liu Yin-Kun, Chang Ta-Yuan, Li Bo-Liang

Abstract excerpt

Humans express two ACAT (acyl-CoA:cholesterol acyltransferase) genes, ACAT1 and ACAT2. ACAT1 is ubiquitously expressed, whereas ACAT2 is primarily expressed in intestinal mucosa and plays an important role in intestinal cholesterol absorption. To investigate the molecular mechanism(s) responsible for the tissue-specific expression of ACAT2, we identified five cis-elements within the human ACAT2 promoter, four for...

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Share to Caco-2 Cells
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CDX2 Transcription Factor

Share to Gene Expression Regulation, Enzymologic

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Homeodomain Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 16274362
DOI: 10.1042/BJ20051417
PMCID: PMC1383711

Genes

ACAT2
CDX2
ACAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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