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EHMT2 promotes the pathogenesis of hepatocellular carcinoma by epigenetically silencing APC expression

3 Aug 2021

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC), the second leading cause of cancer death worldwide, alone accounts for over half (466,100) of new cancer cases and 422,100 deaths based on the average year incidence rates of 2009 to 2011 in China. Due to unclear and complex underlying mechanisms for HCC development, effective therapy for HCC is still unavailable. The Wnt-β-catenin pathway is a critical contributor of...

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PMID: 34344448
DOI: 10.1186/s13578-021-00663-9

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