Article
An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats.
Genes and immunity - 1 Apr 2013
Luo H, Higuchi K, Matsumoto K, Mori M
Abstract excerpt
In previous studies, we identified a loss-of-function mutation in the Cyba gene as the primary cause of hereditary eosinophilia in the Matsumoto Eosinophilia Shinshu (MES) rat strain. We also identified a modifier locus for eosinophilia named eos3 in rats. In this study, we examined the interleukin-33 (Il33) gene as a candidate for the eos3 and found a missense nucleotide substitution in the gene, which resulted...
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