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Article

Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).

Journal of leukocyte biology - 1 Sept 2009

Mori Masayuki, Li Guixin, Hashimoto Maiko, Nishio Ayako, Tomozawa Hiroshi, Suzuki Nobuyoshi, Usami Shin-ichi, Higuchi Keiichi, Matsumoto Kiyoshi

Abstract excerpt

MES is a rat strain that spontaneously develops severe blood eosinophilia as a hereditary trait. Herein, we report that eosinophilia in MES rats is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba; also known as p22(phox)), which is an essential component of the superoxide-generating NADPH oxidase complex. The MES rat has a deletion of four nucleotides, including...

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Identifiers

PMID: 19406829
DOI: 10.1189/jlb.1108715

Genes

CYBA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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