Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4+ T cells.

Human gene therapy methods - 1 Apr 2013

Okamoto Mika, Chono Hideto, Kawano Yasuhiro, Saito Naoki, Tsuda Hiroshi, Inoue Koichi, Kato Ikunoshin, Mineno Junichi, Baba Masanori

Abstract excerpt

Gene therapy using a Tat-dependent expression system of MazF, an ACA nucleotide sequence-specific endoribonuclease derived from Escherichia coli, in a retroviral vector appears to be an alternative approach to the treatment of human immunodeficiency virus type 1 (HIV-1) infection. MazF can cleave HIV-1 RNA, since it has more than 240 ACA sequences. Significant inhibition of viral replication, irrespective of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Multiple, Viral
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Order

Share to Intracellular Space

Share to Retroviridae

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Transduction, Genetic

Share to Viral Tropism

Source

Identifiers

PMID: 23442049
DOI: 10.1089/hgtb.2012.131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4+ T cells.PMID 23442049Read ↗

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected CellsSemantic proximity Read ↗

CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription.Semantic proximity Read ↗

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.Semantic proximity Read ↗

Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.Semantic proximity Read ↗

Detection, characterization and regulation of antisense transcripts in HIV-1Semantic proximity Read ↗

Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particlesSemantic proximity Read ↗

A gene therapy approach to eliminate HIV-1-infected cells.Semantic proximity Read ↗

MxA GTPase Blocks Reporter Gene Expression of Reconstituted Thogoto Virus Ribonucleoprotein ComplexesSemantic proximity Read ↗

Inhibition of HIV Replication in Acute and Chronic Infections in Vitro by a Tat AntagonistSemantic proximity Read ↗

Cells induced to express a human immunodeficiency virus type 1 envelope gene mutant inhibit the spread of wild-type virus.Semantic proximity Read ↗

Inhibition by AZT of HIV-1 replication in acutely infected U-937 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.