Article
Screening for large rearrangements of the RB1 gene in Iranian patients with retinoblastoma using multiplex ligation-dependent probe amplification.
Molecular vision - 1 Jan 2013
Ahani Ali, Akbari Mohammad Taghi, Saliminejad Kioomars, Behnam Babak, Akhondi Mohammad Mehdi, Vosoogh Parvaneh, Ghassemi Farriba, Naseripour Masood, Bahoush Gholamreza, Khorshid Hamid Reza Khorram
Abstract excerpt
PURPOSE: To screen deletions/duplications of the RB1 gene in a large cohort of Iranian patients using the multiplex ligation-dependent probe amplification (MLPA) technique. METHODS: A total of 121 patients with retinoblastoma, involving 55 unilateral and 66 bilateral or familial retinoblastomas, were included in this study. Among these patients, 121 blood and 43 tissue samples were available. DNA was extracted...
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