Article
Mutational screening of germline RB1 gene in Vietnamese patients with retinoblastoma reveals three novel mutations.
Molecular vision - 1 Jan 2018
Nguyen Ha Hai, Nguyen Hoa Thi Thanh, Vu Nhung Phuong, Le Quynh Thuy, Pham Chau Minh, Huyen Thuong Thi, Manh Hung, Pham Hang Le Bich, Nguyen Ton Dang, Le Hien Thi Thu, Van Nong Hai
Abstract excerpt
Purpose: Retinoblastoma (Rb) is a rare and unique eye cancer that usually develops in the retinas of children less than 5 years old due to mutations in the RB1 gene. About 40% of affected individuals have the heritable form making genetics testing of the RB1 gene important for disease management. This study aims to identify germline mutations in RB1 in a cohort of patients with Rb from northern Vietnam. Methods:...
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