Article
LTBP4 genotype predicts age of ambulatory loss in Duchenne muscular dystrophy.
Annals of neurology - 1 Apr 2013
Flanigan Kevin M, Ceco Ermelinda, Lamar Kay-Marie, Kaminoh Yuuki, Dunn Diane M, Mendell Jerry R, King Wendy M, Pestronk Alan, Florence Julaine M, Mathews Katherine D, Finkel Richard S, Swoboda Kathryn J, Gappmaier Eduard, Howard Michael T, Day John W, McDonald Craig, McNally Elizabeth M, Weiss Robert B
Abstract excerpt
OBJECTIVE: Duchenne muscular dystrophy (DMD) displays a clinical range that is not fully explained by the primary DMD mutations. Ltbp4, encoding latent transforming growth factor-β binding protein 4, was previously discovered in a genome-wide scan as a modifier of murine muscular dystrophy. We sought to determine whether LTBP4 genotype influenced DMD severity in a large patient cohort. METHODS: We analyzed...
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