Article
DMD mutation and LTBP4 haplotype do not predict onset of left ventricular dysfunction in Duchenne muscular dystrophy.
Cardiology in the young - 1 Jul 2018
Van Dorn Charlotte S, Puchalski Michael D, Weng Hsin-Yi, Bleyl Steven B, Butterfield Russell J, Williams Richard V
Abstract excerpt
Cardiomyopathy develops in >90% of Duchenne muscular dystrophy (DMD) patients by the second decade of life. We assessed the associations between DMD gene mutations, as well as Latent transforming growth factor-beta-binding protein 4 (LTBP4) haplotypes, and age at onset of myocardial dysfunction in DMD. DMD patients with baseline normal left ventricular systolic function and genotyping between 2004 and 2013 were...
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