Article
The LIM protein fhlA is essential for heart chamber development in zebrafish embryos.
Current molecular medicine - 1 Jul 2013
Xie H, Fan X, Tang X, Wan Y, Chen F, Wang X, Wang Y, Li Y, Tang M, Liu D, Jiang Z, Liu X, Yuan W, Li G, Ye X, Zhou J, Mo X, Deng Y, Wu X
Abstract excerpt
Four-and-a-half LIM proteins FHL1-3 play important roles in cardiovascular pathophysiology. However, their roles in heart development remain unclear. Here, we report that fhlA, the zebrafish homolog of human FHL1, was found to be expressed around the 22-somite stage. After 24 hpf, expression was restricted to the heart. fhlA knockdown caused an enlarged cardiac chamber phenotype with up-regulated expression of...
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