Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FHL2 (SLIM3) is not essential for cardiac development and function.

Molecular and cellular biology - 1 Oct 2000

Chu P H, Bardwell W M, Gu Y, Ross J, Chen J

Abstract excerpt

LIM domain-containing proteins play critical roles in vertebrate development and cellular differentiation. Recently, four members of the four and one-half LIM protein (FHL) family have been identified and cloned. One of these, FHL2, is expressed in a restricted manner in the cardiovascular system throughout development into adulthood, suggesting that FHL2 may play an important role in cardiovascular development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Cardiomegaly
Share to Heart Conduction System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligation

Share to LIM Domain Proteins

Share to LIM-Homeodomain Proteins

Share to Pressure

Share to Stress, Mechanical

Source

Open in PubMed Open full text

Identifiers

PMID: 11003643
DOI: 10.1128/MCB.20.20.7460-7462.2000
PMCID: PMC86299

Genes

FHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FHL2 (SLIM3) is not essential for cardiac development and function.PMID 11003643Read ↗

Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heartSemantic proximity Read ↗

Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues.Semantic proximity Read ↗

Unraveling the role of the FHL family in cardiac diseases: Mechanisms, implications, and future directions.Semantic proximity Read ↗

Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular systemSemantic proximity Read ↗

The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.Semantic proximity Read ↗

Protein–protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular diseaseSemantic proximity Read ↗

Characterization of tissue‐specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM‐only protein (FHL1)Semantic proximity Read ↗

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.Semantic proximity Read ↗

The LIM protein fhlA is essential for heart chamber development in zebrafish embryos.Semantic proximity Read ↗

Luma is not essential for murine cardiac development and function.Semantic proximity Read ↗

klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.Semantic proximity Read ↗

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.